You should seek the advice of your veterinarian if your pet is ill as only he or she can correctly advise on the diagnosis and recommend the treatment that is most appropriate for your pet.

The scientific evidence to support the administration of nutritional supplements to pets is often very weak. Best evidence are randomised controlled trials (RCTs)

S-Adenosyl-L Methionine (SAMe) (n=1 RCT)

In a placebo-controlled RCT (Imhoff 2011) in dogs using objective criteria (platform gait analysis and goniometry) as well as examination score and the Canine Brief Pain Inventory SAMe was found not to reduce clinical signs of OA in dogs (n=33) over a 6 week period.

Evidence : WEAK – No effect

References

Imhoff DJ, Gordon-Evans WJ, Evans RB, Johnson AL, et al. (2011) Evaluation of S¬adenosyl-L-methionine in a double-blinded, randomised, placebo-controlled clinical trial for the treatment of presumptive osteoarthritis in the dog. Veterinary Surgery 40(2): 228-232

Updated September 2015